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Related Experiment Video

Updated: Feb 10, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Quadripolar Leads in Cardiac Resynchronization Therapy.

Wouter M van Everdingen1, Maarten J Cramer1, Pieter A Doevendans1

  • 1Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.

JACC. Clinical Electrophysiology
|May 16, 2018
PubMed
Summary

Quadripolar leads improve cardiac resynchronization therapy (CRT) outcomes for heart failure patients. Optimal lead placement and multipoint pacing enhance patient response, offering a significant advancement in CRT.

Keywords:
cardiac resynchronization therapyleadmultipoint pacingphrenic nerve stimulationquadripolar

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Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Cardiac resynchronization therapy (CRT) benefits heart failure patients with conduction delays, but many show limited response.
  • Left ventricular lead placement is critical for CRT efficacy, influenced by patient anatomy and local heart conditions.

Purpose of the Study:

  • To evaluate the role of quadripolar leads in improving CRT response.
  • To explore the impact of lead configuration and multipoint pacing on patient outcomes.

Main Methods:

  • Review of studies comparing quadripolar leads with standard bipolar leads for CRT.
  • Analysis of acute hemodynamic responses and complication rates associated with quadripolar lead implantation.
  • Examination of patient-specific factors influencing response to different pacing configurations.

Main Results:

  • Quadripolar leads offer multiple pacing options, allowing for optimized lead positioning to improve CRT response.
  • Implantation safety is comparable or improved versus bipolar leads.
  • Optimal pacing vector selection and multipoint pacing show promise for enhanced acute hemodynamic benefits.

Conclusions:

  • Quadripolar leads represent a significant advancement in CRT for heart failure management.
  • Further large-scale trials are needed to confirm long-term benefits and the role of multipoint pacing.