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[Thyroid function and trisomy 21. TSH increase and rT3 deficiency]
J Lejeune1, M Peeters, M C de Blois
1Institut de Progenèse, Centre Claude Bernard sur les Maladies de l'Intelligence, Paris.
Annales De Genetique
|January 1, 1988
Abstract:
An excess of thyrotropin (TSH) with normal levels of tetraiodothyronine (T4) and of 3,5,3'-triiodothyronine (T3) was confirmed in the serum of 78 trisomy 21 children. A severe deficiency of 3,3',5'-triiodo-thyronine (rT3 or reverse T3) was observed and the decrease of the rT3/TSH ratio was highly significant. These new facts suggest that the rT3 deficiency plays a peculiar role in trisomy 21 (maybe through the regulation of one or few steps of monocarbons' metabolism). A systematic control of thyroid function (including the patient's rT3 level) is mandatory for the follow-up of every trisomy 21 patient.