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Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
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Biological aspects of chondrosarcoma: Leaps and hurdles

Benoîte Mery1, Sophie Espenel2, Jean-Baptiste Guy2

  • 1Department of Medical Oncology, Lucien Neuwirth Cancer Institute, St Priest en Jarez, France.

Critical Reviews in Oncology/Hematology
|May 16, 2018
PubMed

Insights

Chondrosarcoma treatment faces challenges due to chemoresistance, necessitating surgical intervention. Understanding resistance mechanisms and targeting key pathways like PI3K/AKT/mTOR offers new therapeutic avenues for chondrosarcoma (CHS).

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Chondrosarcomas (CHS) exhibit significant chemo- and radioresistance.
  • Current treatment relies primarily on surgery, with survival rates varying by grade.
  • Non-surgical treatment strategies require a deeper understanding of resistance mechanisms.

Purpose of the Study:

  • To review the biological challenges in treating chondrosarcoma.
  • To explore major signaling pathways involved in chondrosarcoma proliferation and invasion.
  • To identify potential molecular targets for novel therapeutic approaches.

Main Methods:

  • Literature review of chondrosarcoma biology and treatment resistance.
  • Analysis of key signaling pathways implicated in chondrosarcoma progression.
  • Identification of potential therapeutic targets based on biological understanding.

Main Results:

  • Survival pathways (PI3K, AKT, mTOR, VEGF) are crucial for chondrosarcoma cell proliferation.
  • Antiapoptotic proteins and targets like p53 and COX2 are implicated in resistance.
  • Targeted therapies offer potential new treatment options.

Conclusions:

  • Improved understanding of chondrosarcoma biology is essential for developing effective non-surgical treatments.
  • Targeting specific signaling pathways and proteins presents a promising strategy for novel chondrosarcoma therapies.
  • Novel targeted therapies could overcome chemo- and radioresistance in chondrosarcoma.
Keywords:
BiologyChemo and radiation resistanceChondrosarcomaSignaling pathways

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