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Updated: Feb 10, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Angiographic Efficacy of the Atriclip Left Atrial Appendage Exclusion Device Placed by Minimally Invasive
Christopher R Ellis1, Sam G Aznaurov1, Neel J Patel1
1Vanderbilt University Medical Center, Nashville, Tennessee.
Insights
The Atriclip device, applied via a totally thoracoscopic approach, demonstrates high efficacy for left atrial appendage closure. This minimally invasive method shows promising results for preventing atrial fibrillation-related embolic stroke.
Area of Science:
- Cardiology
- Minimally Invasive Surgery
- Medical Devices
Background:
- Left atrial appendage (LAA) closure reduces embolic stroke risk in atrial fibrillation.
- The Atriclip device enables epicardial LAA closure, potentially avoiding oral anticoagulation.
- Prior studies of open-chest Atriclip procedures show >95% closure efficacy.
Purpose of the Study:
- To evaluate the long-term efficacy of Atriclip for LAA closure using a totally thoracoscopic (TT) approach.
- To assess the rate of complete LAA exclusion via computed tomographic angiography (CTA) at least 90 days post-implantation.
Main Methods:
- Retrospective analysis of patients who received TT-placed Atriclip at Vanderbilt University Medical Center (2011-2015).
- Three-dimensional, 2-phase CTA performed ≥90 days post-implantation.
- Independent radiological assessment for complete LAA closure defined by specific criteria.
Main Results:
- Complete LAA closure was achieved in 93.9% (61/65) of subjects.
- Incomplete closure occurred in 6.2% (4/65) due to device placement or secondary lobe issues.
- No major complications were noted with TT Atriclip placement; one stroke occurred in a patient with complete closure.
Conclusions:
- TT-placed Atriclip achieves high angiographic LAA closure efficacy (93.9%).
- The clinical impact of residual LAA stumps requires further investigation.
- Confirming complete LAA occlusion is crucial before discontinuing anticoagulation.
Objectives:
This study sought to assess long-term left atrial appendage (LAA) closure efficacy of the Atriclip applied via totally thoracoscopic (TT) approach with computed tomographic angiography.
Background:
LAA closure is associated with a low risk for atrial fibrillation-related embolic stroke. The Atriclip exclusion device allows epicardial LAA closure, avoiding the need for post-operative oral anticoagulation. Previous data with Atriclip during open chest procedures show a high efficacy rate of closure >95%.
Methods:
Three-dimensional volumetric 2-phase computed tomographic angiography ≥90 days post-implantation was independently assessed by chest radiology for complete LAA closure on all consented subjects identified retrospectively as having had a TT-placed Atriclip at Vanderbilt University Medical Center from June 13, 2011, to October 6, 2015.
Results:
Complete LAA closure (defined by complete exclusion of the LAA with no exposed trabeculations, and clip within 1 cm from the left circumflex artery) was found in 61 of 65 subjects (93.9%). Four cases had incomplete closure (6.2%). Two clips were placed too distally, leaving a large stump with exposed trabeculae. Two clips failed to address a secondary LAA lobe. No major complications were associated with TT placement of the Atriclip. Follow-up over 183 patient-years revealed 1 stroke in a patient with complete LAA closure and no thrombus (hypertensive cerebrovascular accident).
Conclusions:
Angiographic LAA closure efficacy with a TT-placed Atriclip is high (93.9%). The clinical significance of a remnant stump is unknown. Confirmation of complete LAA occlusion should be made before cessation of systemic anticoagulation.
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