[2016 WHO Classification of Tumors of CNS: A Paradigm Shift from Histologic to Molecular Classification]

With the recent development in molecular genetics, the WHO classification of CNS tumors was revised in 2016. The new WHO classification made a paradigm shift from traditional histologic classification to molecular classification. In particular, integrated diagnoses that combined morphologic and molecular information were introduced for diffuse gliomas and embryonal tumors. The new classification is expected to result in more accurate diagnosis, appropriate therapeutic strategy, precise prediction of prognosis, etc. Practical efforts have already been started at the clinical sites to adapt to the new classification.