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Quinten van Geest1, Hanneke E Hulst1, Kim A Meijer1

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Summary

Dynamic functional connectivity in the hippocampus is crucial for memory performance in multiple sclerosis (MS). Lower hippocampal dynamic functional connectivity (dFC) is linked to poorer verbal and visuospatial memory in MS patients.

Keywords:
cognitiondynamic functional connectivityfunctional magnetic resonance imaginghippocampusmemorymultiple sclerosis

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Medical Imaging

Background:

  • Brain dynamics, or changing communication between brain areas, are vital for cognitive functions like memory.
  • Memory impairments are common in multiple sclerosis (MS), often linked to static brain measures.
  • Dynamic functional connectivity (dFC) of the hippocampus in MS and its relation to memory remains underexplored.

Purpose of the Study:

  • To investigate hippocampal dynamic functional connectivity (dFC) during an episodic memory task in MS patients.
  • To examine the relationship between hippocampal dFC and both verbal and visuospatial memory performance.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to capture brain activity during a memory task in 38 MS patients and 29 controls.
  • Hippocampal volume, activation, stationary functional connectivity (sFC), and dynamic functional connectivity (dFC) were assessed.
  • dFC was calculated using a sliding window approach.

Main Results:

  • No significant group differences were observed in hippocampal activation, sFC, or dFC.
  • In MS patients, lower left hippocampal dFC predicted poorer verbal memory performance.
  • Lower right hippocampal dFC and higher right hippocampal sFC predicted poorer visuospatial memory performance.

Conclusions:

  • Hippocampal dFC is a significant indicator of memory function in MS, beyond static measures.
  • Brain dynamics, specifically hippocampal dFC, offer novel insights into the neurobiology of memory deficits in MS.