Associations between apparent diffusion coefficient and electromyography parameters in myositis-A preliminary study

MRI is widely used in several muscle disorders. Diffusion-weighted imaging (DWI) is an emergent imaging modality sensitive to microstructural alterations in tissue. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules. Electromyography (EMG) is a clinically used diagnostic tool in myositis. The aim of this study was to elucidate possible associations between ADC values and EMG findings in myositis patients.

Seven patients (eight investigated muscles) with myositis (mean age 51.43 ± 19 years) were included in this study. The diagnosis was confirmed by histopathology in every case. DWI was obtained with a 1.5-T scanner using two b-values 0 and 1000 s/mm². In all patients, a needle electromyography (EMG) was performed within 3 days to the MRI. The following EMG parameters were studied: motor unit action potential (MUAP) amplitudes and durations, as well as pathological spontaneous activity. Spearman's correlation coefficient was used to analyze associations between investigated parameters.

The estimated mean ADC _mean value was 1.51 ± 0.29 × 10^-3 mm²/s, mean ADC _min was 1.28 ± 0.27 × 10^-3 mm²/s, and mean ADC _max was 1.73 ± 0.28 × 10^-3 mm²/s. Correlation analysis identified significant associations between ADC _mean and duration of the MUAP (p = .78 P = .0279) and between ADC _min and duration of the MUAP (p = .85, P = .01). There were no significant differences according to pathological spontaneous activity.

ADC _mean and ADC _min showed strong positive correlations with the duration of the MUAP in myositis patients. Both modalities might similarly reflect muscle fiber loss in myositis patients.