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[Chronic hepatitis B and D (delta) : Current and future treatments]
N Wortmann1, C Höner Zu Siederdissen1, M Cornberg2,3,4
1Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Der Internist
|May 16, 2018
Summary
Current hepatitis B virus (HBV) therapies suppress HBV DNA, reducing liver fibrosis and cancer risk. New treatments offer hope for a functional cure of HBV and better options for hepatitis delta coinfection.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Hepatitis B virus (HBV) infection is a major global health concern and a leading cause of death.
- Chronic hepatitis delta coinfection accelerates disease progression, posing significant clinical challenges.
Purpose of the Study:
- To provide an overview of current and emerging therapeutic strategies for chronic hepatitis B and hepatitis delta.
- To synthesize findings based on international guidelines and recent research.
Main Methods:
- Review of existing international guidelines and published studies on hepatitis B and delta therapies.
- Analysis of preclinical and clinical data for novel therapeutic approaches.
Main Results:
- Nucleoside/nucleotide analogue therapy effectively suppresses HBV DNA, leading to liver fibrosis regression and reduced hepatocellular carcinoma risk.
- Pegylated interferon alfa for chronic hepatitis delta shows limited efficacy and high relapse rates.
- Investigational therapies demonstrate significant reductions in hepatitis B surface antigen (HBsAg) and HDV RNA.
Conclusions:
- Existing therapies for chronic HBV infection can mitigate disease complications.
- Emerging therapeutic strategies hold promise for achieving a functional cure (HBsAg loss) for HBV infection and effective treatment for chronic hepatitis delta.
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