PCL-Based Composite Scaffold Matrices for Tissue Engineering Applications
Nadeem Siddiqui1, Simran Asawa1, Bhaskar Birru1
1Stem Cell Research Laboratory, Department of Biotechnology, NIT Warangal, Warangal, Telangana, 506004, India.
Molecular Biotechnology
|May 16, 2018
Summary
Polycaprolactone (PCL) is a versatile biomaterial for tissue engineering (TE) scaffolds. This review details PCL synthesis, properties, and applications in TE, including blends and various scaffold forms for tissue repair.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Biomaterial scaffolds are crucial for tissue engineering (TE).
- Recent TE advances focus on scaffold architecture for tissue defects.
- Polycaprolactone (PCL) is a widely studied synthetic polymer for TE.
Purpose of the Study:
- To provide a comprehensive narrative review of polycaprolactone (PCL) in tissue engineering.
- To discuss PCL synthesis, properties, and recent advancements.
- To explore PCL's application in various TE strategies, including blends and scaffold forms.
Main Methods:
- Literature review focusing on polycaprolactone (PCL) synthesis, properties, and applications.
- Analysis of PCL blended with natural/synthetic polymers and ceramic materials.
- Examination of different PCL scaffold architectures (porous, films, fibrous).
Main Results:
- PCL exhibits favorable properties for TE applications.
- PCL blends with other materials enhance scaffold performance.
- Various PCL scaffold forms are suitable for different tissue repair strategies.
- Stem cells and their sources are key components in PCL-based TE.
Conclusions:
- Polycaprolactone (PCL) is a highly adaptable biomaterial for diverse tissue engineering applications.
- The review highlights PCL's potential in developing advanced scaffolds for tissue regeneration.
- Further research into PCL-based materials and strategies will advance tissue repair.
Related Concept Videos
01:17Solution Composition During Acid/Base Titrations
1.6K
The titration of a weak acid with a strong base results in the formation of water and the conjugate base of the acid. For instance, titrating acetic acid with sodium hydroxide leads to the formation of water and sodium acetate. A solution of acetic acid and sodium acetate constitutes a buffer whose relative concentration at different stages of the titration is indicated by the α values, which represent percentages of the weak acid and its conjugate base.
The α0 and α1 values...
The α0 and α1 values...
1.6K
03:35Classifying Matter by Composition
91.0K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
91.0K
00:49What is Genetic Engineering?
80.4K
Overview
80.4K
00:55Composite Bodies
1.4K
A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
1.4K
01:22Composition of Blood
12.5K
The blood in our bodies comprises three major components: blood plasma, formed elements, and the extracellular matrix. Blood plasma is a yellowish fluid that constitutes 55% of the total blood volume. It is primarily made up of water and essential substances such as electrolytes and proteins. Blood plasma serves as a medium for transporting blood cells and also contains nutrients, enzymes, hormones, antibodies, and gases.
Formed elements constitute the remaining 45% of the blood volume. These...
Formed elements constitute the remaining 45% of the blood volume. These...
12.5K
01:29Composition of Body Fluids
2.7K
Water functions as a solvent accommodating various solutes, which can be categorized under electrolytes and non-electrolytes. Non-electrolytes are usually held together by covalent bonds, restricting them from dissociating in solution, thereby leading to a lack of electrically charged components upon dissolving in water. They are predominantly organic molecules, such as glucose, creatinine, and urea. Electrolytes, on the other hand, are compounds that can break down into ions in water.
2.7K