Related Experiment Video
Updated: Feb 10, 2026
Measuring Diffusion Coefficients via Two-photon Fluorescence Recovery After Photobleaching
Published on: February 26, 2010
Radiomics analysis of apparent diffusion coefficient in cervical cancer: A preliminary study on histological grade
Ying Liu1, Yuwei Zhang1,2, Runfen Cheng3
1Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Background:
The role of apparent diffusion coefficient (ADC)-based radiomics features in evaluating histopathological grade of cervical cancer is unresolved.
Purpose:
To determine if there is a difference between radiomics features derived from center-slice 2D versus whole-tumor volumetric 3D for ADC measurements in patients with cervical cancer regarding tumor histopathological grade, and systematically assess the impact of the b value on radiomics analysis in ADC quantifications.
Study Type:
Prospective.
Subjects:
In all, 160 patients with histopathologically confirmed squamous cell carcinoma of uterine cervix.
Field Strength/Sequence:
Conventional and diffusion-weighted MR images (b values = 0, 800, 1000 s/mm2 ) were acquired on a 3.0T MR scanner.
Assessment:
Regions of interest (ROIs) were drawn manually along the margin of tumor on each slice, and then the center slice of the tumor was selected with naked eyes in the course of whole-tumor segmentation. A total of 624 radiomics features were derived from T2 -weighted images and ADC maps. We randomly selected 50 cases and did the reproducibility analysis.
Statistical Tests:
Parameters were compared using Wilcoxon signed rank test, Bland-Altman analysis, t-test, and least absolute shrinkage and selection operator (LASSO) regression with crossvalidation.
Results:
In all, 95 radiomics features were insensitive to ROI variation among T2 images, ADC map of b800, and ADC map of b1000 (P > 0.0002). There was a significant statistical difference between the performances of 2D center-slice and 3D whole-tumor radiomics models in both ADC feature sets of b800 and b1000 (P < 0.0001, P < 0.0001). Compared with ADC features of b800 (0.3758 ± 0.0118), the model of b1000 ADC features appeared to be slightly lower in overall misclassification error (0.3642 ± 0.0162) (P = 0.0076).
Data Conclusion:
Several radiomics features extracted from T2 images and ADC maps were highly reproducible. Whole-tumor volumetric 3D radiomics analysis had a better performance than using the 2D center-slice of tumor in stratifying the histological grade of cervical cancer. A b value of 1000 s/mm2 is suggested as the optimal parameter in pelvic DWI scans.
Level Of Evidence:
1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:280-290.
Related Concept Videos
01:19Sieve Analysis and Grading Curves
01:09Apparent Weight
Consider a person standing on a bathroom scale inside an elevator. If the scale is accurate at rest, its reading equals the...
01:12Diffusion
01:10Coefficient of Variation
The coefficient of variation is a practical statistical tool in finance. It allows investors to assess the volatility or...
01:28Apparent Weight and the Earth's Rotation
For an object on the Earth's equator, the net centripetal force that accounts for its rotation is the Earth's pull towards its center, or the weight minus the normal force that prevents it from piercing into the Earth's surface....
01:12Coefficient of Correlation
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...