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Related Concept Videos

Redox Reactions01:24

Redox Reactions

58.9K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
58.9K
Redox Reactions01:27

Redox Reactions

1.1K
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
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Balancing Redox Equations02:58

Balancing Redox Equations

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Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
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Redox Equilibria: Overview01:23

Redox Equilibria: Overview

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A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...
1.6K
Redox Titration: Overview01:21

Redox Titration: Overview

5.0K
Redox titration is a chemical analysis technique used to determine the concentration of an unknown substance by measuring the electron transfer in a redox (reduction-oxidation) reaction. The process involves gradually adding a titrant with a known concentration of an oxidizing or reducing agent, to the analyte, the solution with an unknown concentration, until reaching the endpoint, which indicates the completion of the reaction between the two substances. Ensuring the analyte is in a single...
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Molecules and Compounds02:38

Molecules and Compounds

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Atoms and Molecules
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Cellular Redox Profiling Using High-content Microscopy
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Redox-guided small molecule antimycobacterials.

Amogh Kulkarni1, Ajay Kumar Sharma1, Harinath Chakrapani1

  • 1Department of Chemistry, Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pune, Maharashtra, India.

IUBMB Life
|May 16, 2018
PubMed
Summary
This summary is machine-generated.

Drug-resistant tuberculosis requires new treatments. This review explores small molecules that induce redox stress, offering potential new mechanisms of action against challenging mycobacterial infections.

Keywords:
antioxidantsdrug discoveryoxidative stressredox homeostasisthiols

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Area of Science:

  • Biochemistry
  • Microbiology
  • Drug Discovery

Background:

  • Drug resistance in tuberculosis (TB) presents a significant global health challenge.
  • Limited new antimycobacterial drug candidates necessitate novel therapeutic strategies.
  • Mycobacterial survival relies on maintaining redox homeostasis.

Purpose of the Study:

  • To review small molecules designed to induce redox stress in mycobacteria.
  • To explore the potential of redox-modulating compounds against drug-resistant TB.
  • To discuss the progress and challenges of redox-guided antimycobacterial drug development.

Main Methods:

  • Literature review of small molecules targeting mycobacterial redox balance.
  • Analysis of compounds that induce oxidative stress for antimycobacterial activity.
  • Evaluation of efficacy against drug-resistant mycobacterial strains.

Main Results:

  • Several small molecules effectively induce redox stress in mycobacteria.
  • These compounds demonstrate significant activity against drug-resistant strains.
  • Redox-guided approaches offer potential novel mechanisms of action.

Conclusions:

  • Perturbing redox homeostasis is a viable strategy for antimycobacterial drug development.
  • Redox-modulating compounds show promise for treating drug-resistant tuberculosis.
  • Further research is needed to overcome challenges in clinical applications.