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Updated: Feb 10, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis:
Cinda L Hugos1, Michelle H Cameron1, Zunqiu Chen2
1VA Portland Health Care System, Oregon Health and Sciences University, Portland, OR, USA.
Background:
A four-site RCT of Fatigue: Take Control (FTC), a multicomponent group program, found no significant differences from a control program, MS: Take Control (MSTC), in fatigue on the Modified Fatigue Impact Scale (MFIS) through 6 months.
Objective:
Assess FTC for a delayed effect on fatigue.
Methods:
Of 78 subjects at one site, 74 randomized to FTC or MSTC completed the MFIS at 12 months.
Results:
Compared to baseline, FTC produced greater improvements in MFIS scores than MSTC (FTC -8.9 (confidence interval (CI): 32.2, 45), MSTC -2.5 (CI 39.6, 47.7), p = 0.03) at 12 months.
Conclusion:
The delayed effect of FTC on fatigue suggests the need for longer follow-up when assessing interventions for fatigue.
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