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Liver-specific growth factors.

W E Fleig1

  • 1Dept. of Internal Medicine II (Gastroenterology and Nutrition), University of Ulm, FRG.

Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1988
PubMed
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Researchers are investigating liver-specific growth factors, including platelet growth factor (PGF) and hepatic stimulator substance (HSS). These factors influence hepatocyte proliferation, but their precise roles remain under investigation.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Cellular Growth Regulation

Background:

  • Liver-specific growth factors have been studied for over 20 years.
  • Hepatocyte growth can be stimulated by plasma and platelet-derived factors.
  • Platelet growth factor (PGF) has been isolated from rat platelets.

Purpose of the Study:

  • To review the evidence for various liver-specific growth factors.
  • To discuss the purification status and activity of identified factors.
  • To highlight the ongoing research into the control of hepatocyte proliferation.

Main Methods:

  • Review of experimental evidence and published studies.
  • Description of factor isolation and partial purification techniques.
  • Analysis of in vitro and in vivo experimental findings.

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Main Results:

  • Platelet growth factor (PGF) isolated from rat platelets.
  • Identification of hepatopoietins A and B from rat plasma.
  • Partial purification of hepatic stimulator substance (HSS) with activity on hepatoma cells.

Conclusions:

  • Several liver-specific growth factors have been identified, but most are not purified to homogeneity.
  • The exact significance of these factors in controlling normal and transformed hepatocyte proliferation is still unclear.
  • Further research is needed to fully elucidate the roles of these growth factors.