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Updated: Feb 10, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[Degree centrality of the functional network in schizophrenia patients]
Mingjun Duan1, Yuchao Jiang2, Xi Chen2
1Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P.R.China;The Fourth People's Hospital of Chengdu, Chengdu 610036, P.R.China.
Abstract:
The aim of the present study was to investigate the alternations of brain functional networks at resting state in the schizophrenia (SCH) patients using voxel-wise degree centrality (DC) method. The resting-state functional magnetic resonance imaging (rfMRI) data were collected from 41 SCH patients and 41 matched healthy control subjects and then analyzed by voxel-wise DC method. The DC maps between the patient group and the control group were compared using by two sample t test. The correlation analysis was also performed between DC values and clinical symptom and illness duration in SCH group. Results showed that compared with the control group, SCH patients exhibited significantly decreased DC value in primary sensorimotor network, and increased DC value in executive control network. In addition, DC value of the regions with obvious differences between the two groups significantly correlated to Positive and Negative Syndrome Scale (PANSS) scores and illness duration of SCH patients. The study showed the abnormal functional integration in primary sensorimotor network and executive control network in SCH patients.
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