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[Research progress of competing endogenous RNA].

Lin Wang1, Jie Liu2

  • 1The 2nd clinical college of China Medical University, Shenyang 110013, P.R.China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|May 16, 2018
PubMed
Summary

The competing endogenous RNA (ceRNA) hypothesis explains how various RNA molecules regulate gene expression by interacting with microRNAs (miRNAs). This regulatory network is crucial in both normal physiology and disease development, including cancer.

Keywords:
competing endogenous RNAmicroRNA response elementmicroRNAsposttranscriptional regulation

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Area of Science:

  • Molecular Biology
  • Genetics
  • Gene Regulation

Context:

  • The competing endogenous RNA (ceRNA) hypothesis describes a novel mechanism of posttranscriptional gene regulation.
  • ceRNAs, including mRNA, long noncoding RNA (lncRNA), pseudogene transcripts, and circular RNA (circRNA), modulate gene expression by sponging microRNAs (miRNAs).
  • ceRNA regulatory networks are implicated in maintaining physiological homeostasis and the pathogenesis of various diseases.

Purpose:

  • To review the proposal and evolution of the ceRNA hypothesis.
  • To identify the components and members of ceRNA regulatory networks.
  • To discuss the current research status, limitations, and future directions of ceRNA research.

Summary:

  • This review elucidates the competing endogenous RNA (ceRNA) hypothesis, a key mechanism in posttranscriptional gene regulation.
  • It details the diverse RNA molecules acting as ceRNAs and their interaction with microRNAs (miRNAs).
  • The review covers the establishment of the ceRNA hypothesis, its network members, current research, challenges, and future prospects.

Impact:

  • Understanding ceRNA networks offers insights into disease pathogenesis, particularly in oncology.
  • This knowledge can pave the way for novel diagnostic and therapeutic strategies for various diseases.
  • The ceRNA hypothesis provides a framework for exploring complex gene regulatory interactions.