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Plasma fibronectin levels in patients with idiopathic ulcerative colitis
R Kochhar1, N Kumar1, V Singh1
1Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Background:
Deficiency of fibronectin-a naturally occurring glycoprotein-has been demonstrated in patients with Crohn's disease. We studied plasma fibronectin levels in idiopathic ulcerative colitis to see whether there was any correlation with disease activity.
Methods:
Fifty patients and an equal number of age and sex matched healthy controls were studied by ELISA for plasma fibronectin.
Results:
The mean plasma fibronectin levels were significantly lower (p<0.001) in patients with idiopathic ulcerative colitis (171±93 μg/ml) as compared to those in controls (347±59 μg/ml). There was, however, no significant difference (p>0.05) in fibronectin levels between those who had active colitis (176±103 μg/ml) and those with quiescent colitis (163±73 μg/ml). Plasma fibronectin levels did not show any correlation with the extent and duration of colitis or with steroid administration.
Conclusion:
Decreased fibronectin levels may be important in the pathophysiology of ulcerative colitis.
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