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Updated: Feb 10, 2026

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
Published on: December 21, 2021
Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus
Sarah R McCoski1, Rebecca K Poole1, McCauley T Vailes1
1Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, USA.
Abstract:
The influence of exposure to overfeeding-induced maternal obesity around the time of conception on early embryogenesis was examined in the day 14 ovine conceptus. The relative abundance of FGFR2 and DNMT1 was influenced by maternal obesity status and conceptus sex, and the abundance of PPARG and PTGS2 transcripts was greater in male conceptuses regardless of the obesity status of the ewe. These observations demonstrated that short-term exposure to maternal obesity impacts early conceptus transcript patterning.
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