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Related Concept Videos

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If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
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Data collection refers to a systematic way of obtaining, observing, measuring, and analyzing accurate information. Observational studies are one of the most widely used methods of data collection. It involves collecting data by observing the behavior and physical characteristics of a sample without making any modifications to the sample.
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Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: EasyFlow - An Economical and Adaptable Perfusion Bioreactor for Large Blood Vessel Culture
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FABRICA: A Bioreactor Platform for Printing, Perfusing, Observing, & Stimulating 3D Tissues.

Lester J Smith1,2, Ping Li3, Mark R Holland4

  • 1Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. smitlej@iu.edu.

Scientific Reports
|May 17, 2018
PubMed
Summary

FABRICA is a novel 3D-printed bioreactor platform for tissue engineering. It enables real-time monitoring and control of perfusion in 3D-bioprinted tissue constructs, enhancing cell viability.

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Biomedical Engineering

Background:

  • 3D bioprinting enables the creation of complex tissue constructs.
  • Perfusion is crucial for nutrient delivery and waste removal in engineered tissues.
  • Existing bioreactor platforms may lack flexibility and real-time analysis capabilities.

Purpose of the Study:

  • To introduce FABRICA, a bioprinter-agnostic 3D-printed bioreactor platform.
  • To evaluate FABRICA's performance in culturing, perfusing, and analyzing 3D-bioprinted tissue constructs.
  • To assess the impact of perfusion on cell viability in engineered tissues.

Main Methods:

  • FABRICA was designed using computer-aided design and 3D-printed with biocompatible materials.
  • A Flow Profile Study analyzed media perfusion through synthetic constructs using ultrasonic analysis.
  • A Construct Perfusion Study compared histological outcomes of perfused vs. non-perfused 3D-bioprinted tissue constructs over one week.

Main Results:

  • Construct volumetric flow rate (VFR) increased with increasing pump VFR, with water and media showing significant increases compared to blood.
  • Histological analysis confirmed higher cell viability in the perfused 3D-bioprinted tissue construct compared to the non-perfused control.
  • FABRICA demonstrated real-time, aseptic visualization and ultrasonic analysis of perfusion.

Conclusions:

  • FABRICA is a versatile, bioprinter-agnostic platform for 3D-bioprinted tissue culture and perfusion.
  • The platform facilitates real-time monitoring and control, crucial for optimizing engineered tissue development.
  • FABRICA's tunable nature makes it suitable for various tissue types, advancing tissue engineering research.