Fatal hemoptysis in patients with advanced esophageal cancer treated with apatinib

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Wei Wang1, Lin Zhang1, Yan Xie1

  • 1Department of Thoracic Surgery, The Affiliated Qianfoshan Hospital of Shandong University, Jinan, China.

Oncotargets and Therapy
|May 17, 2018
PubMed

Insights

Apatinib shows promise in treating advanced esophageal cancer by reducing tumors and improving quality of life. However, careful patient selection is crucial due to the risk of fatal hemorrhage, particularly when tumors erode major blood vessels.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Targeted therapy offers advantages over traditional chemotherapy for advanced cancers.
  • Apatinib, a tyrosine kinase inhibitor, is approved for gastric and gastroesophageal junction cancers.
  • Limited data exists on apatinib's efficacy in esophageal cancer.

Purpose of the Study:

  • To evaluate the safety and efficacy of apatinib in patients with advanced esophageal cancer.
  • To assess the impact of apatinib on tumor response and patient quality of life.

Main Methods:

  • Case study of two patients with advanced esophageal cancer receiving oral apatinib.
  • Assessment of clinical symptoms, quality of life, and tumor response via chest computed tomography.

Main Results:

  • Both patients experienced improved dyspnea and quality of life.
  • Significant tumor necrosis and reduction were observed.
  • Both patients ultimately died from massive hemoptysis, likely due to tumor erosion of the bronchial artery.

Conclusions:

  • Apatinib demonstrates potential efficacy in advanced esophageal cancer, with controllable side effects.
  • Careful patient selection and monitoring are essential, especially regarding the risk of fatal hemorrhage in patients with tumor erosion near large vessels.
Keywords:
VEGFR-2angiogenesis inhibitoresophageal carcinomahemoptysistargeted drug

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