Recurrent Bleedings in Newborn: A Factor VII Deficiency Case Report

Area of Science:

• Pediatrics
• Hematology
• Genetics

Background:

• Neonatal hemorrhages present a diagnostic challenge, necessitating a thorough understanding of differential diagnoses.
• Prompt recognition and appropriate management are critical for improving outcomes in newborns with bleeding disorders.

Observation:

• A male newborn presented with recurrent hemorrhages from early infancy.
• Initial laboratory tests revealed normal platelet counts, hepatic function, and C-reactive protein levels.
• Coagulation screening identified isolated prolonged prothrombin time (PT) and severe factor VII (FVII) deficiency.

Findings:

• Inherited factor VII deficiency is a rare autosomal recessive disorder.
• Clinical manifestations are variable, and bleeding severity does not correlate directly with FVII levels.
• Treatment options include human plasma-derived FVII (pdFVII) or recombinant activated FVII (rFVIIa) for acute bleeding.

Implications:

• Early diagnosis of FVII deficiency is essential for effective management.
• Prophylaxis should be considered in cases of severe deficiency.
• Increased awareness among clinicians can lead to timely intervention and improved patient care.