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Up-Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds.

Rafael Gonzalez-Cano1, Bruno Boivin1, Daniel Bullock1

  • 1Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, United States.

Frontiers in Pharmacology
|May 17, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces the Up-Down Reader (UDReader) software to automate the analysis of von Frey fiber tests for pain research. The tool accurately determines 50% pain thresholds from handwritten data, saving time and improving accuracy.

Keywords:
QSTallodyniabehaviorfree softwaremechanicaltactileup–downvon Frey

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Area of Science:

  • Neuroscience
  • Pain Research
  • Biomedical Engineering

Background:

  • Pathological pain conditions alter mechanosensation, commonly measured using von Frey fibers.
  • The up-down testing paradigm is a standard method for determining von Frey thresholds in patients and rodents.
  • Manual analysis of up-down data to find 50% thresholds is time-consuming and prone to errors.

Purpose of the Study:

  • To develop an automated software solution for analyzing von Frey fiber test data.
  • To improve the efficiency and accuracy of determining 50% pain thresholds.

Main Methods:

  • Development of the Up-Down Reader (UDReader) computer program.
  • The UDReader software processes scanned PDF documents containing handwritten von Frey assessments.
  • Automated recognition and translation of measurements into 50% pain thresholds.

Main Results:

  • The UDReader program automates the calculation of 50% pain thresholds from primary data.
  • Eliminates the need for manual data entry, reference tables, or complex formulas.
  • Reduces potential for manual calculation errors and saves research time.

Conclusions:

  • The UDReader software offers a simple, accurate, and time-saving method for analyzing von Frey test data.
  • Automating this process enhances data collection accuracy in pain research.
  • The software is freely available for use in scientific research.