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Updated: Feb 10, 2026
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
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Renin-angiotensin-aldosterone inhibition improves right ventricular function: a meta-analysis
Jacob Y Cao1, Seung Yeon Lee1, Kevin Phan1,2
1Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Heart Asia
|May 17, 2018
Summary
Renin-angiotensin-aldosterone system (RAAS) inhibition shows a trend toward improving right ventricular (RV) ejection fraction in patients with or at risk of RV dysfunction. Angiotensin receptor blockers may be particularly beneficial, warranting further investigation in larger trials.
Area of Science:
- Cardiology
- Pharmacology
Background:
- The benefits of renin-angiotensin-aldosterone system (RAAS) inhibition are established for left ventricular dysfunction.
- Its role in right ventricular (RV) dysfunction remains unclear.
Purpose of the Study:
- To investigate the effect of RAAS inhibition on RV function in individuals with or at risk of RV dysfunction.
- To synthesize evidence from existing studies through a meta-analysis.
Main Methods:
- Systematic search of Medline, PubMed, EMBASE, and Cochrane Libraries.
- Inclusion of 12 studies with 265 patients in the RAAS inhibition group and 265 in the placebo group.
- Statistical synthesis to evaluate RV ejection fraction and other parameters.
Main Results:
- A trend towards increased RV ejection fraction was observed in the RAAS inhibition group (WMD=0.95, p=0.08).
- Angiotensin receptor blockers showed a trend towards improving RV ejection fraction (WMD=1.11, p=0.06), unlike ACE inhibitors.
- No significant differences were found in maximal oxygen consumption, RV volumes, exercise testing duration, or heart rate.
Conclusions:
- RAAS inhibition, especially with angiotensin receptor blockers, may play a role in managing RV dysfunction.
- Larger prospective trials are needed to confirm these findings and establish definitive clinical recommendations.
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