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Surface characterization of nanoparticles using near-field light scattering
Eunsoo Yoo1, Yizhong Liu1, Chukwuazam A Nwasike1
1Department of Biomedical Engineering, Binghamton University (SUNY), P.O. Box 6000 Binghamton, NY 13902, USA.
Beilstein Journal of Nanotechnology
|May 17, 2018
Summary
This study modified poly(ethylene glycol)-coated superparamagnetic iron oxide nanoparticles (PEG-SPIOs) with polygallol using interpolymer complexation. Near-field light scattering effectively measured changes in nanoparticle characteristics and colloidal stability.
Area of Science:
- Nanotechnology
- Materials Science
- Colloid Chemistry
Background:
- Colloidal stability of nanoparticles is crucial for biomedical applications.
- Surface modification of nanoparticles impacts their behavior in solution.
- Poly(ethylene glycol)-coated superparamagnetic iron oxide nanoparticles (PEG-SPIOs) are widely used.
Purpose of the Study:
- To explore the modification of PEG-SPIOs with polygallol via interpolymer complexation (IPC).
- To assess changes in nanoparticle size and zeta potential.
- To investigate the suitability of near-field light scattering for characterizing these changes.
Main Methods:
- Modification of PEG-SPIOs with polygallol using interpolymer complexation (IPC).
- Assessment of particle size and zeta potential indirectly via near-field light scattering (NFLS).
- Utilized nanophotonic force microscopy (NanoTweezer™ instrument) with an analytical model.
Main Results:
- Near-field light scattering detected changes in hydrated particle characteristics after surface modification.
- Particle velocity and scattering intensity correlated with particle size and zeta potential.
- Salt concentration influenced particle velocity by altering solution dielectric constant and viscosity.
Conclusions:
- Near-field light scattering is a suitable technique for studying nanoparticle surface changes.
- The method can potentially be used for dynamic studies of surface reaction kinetics.
- Surface modification via IPC alters colloidal properties of PEG-SPIOs.
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