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Related Concept Videos

Nursing Interventions I: Taxonomy of Nursing Interventions01:03

Nursing Interventions I: Taxonomy of Nursing Interventions

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Nursing interventions are chosen as part of the planning process to achieve patient outcomes. Once nursing diagnoses are determined, the goals and outcomes are specified, then the nursing interventions are selected and individualized according to the patient's situation.
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
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Nursing Interventions II: Selecting and Classifying the Nursing Interventions01:29

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

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Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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Exercise Stress Test01:26

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Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
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Community Based Intervention01:30

Community Based Intervention

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Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
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What is Behavior?00:54

What is Behavior?

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Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
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Related Experiment Video

Updated: Feb 10, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
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Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior.

Sucharita S Somkuwar1, Miranda C Staples1, McKenzie J Fannon1

  • 1Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

Brain Plasticity (Amsterdam, Netherlands)
|May 17, 2018
PubMed
Summary

Voluntary exercise may reduce methamphetamine addiction and relapse by improving brain function. This review explores how physical activity impacts methamphetamine use and neurobiology in preclinical models.

Keywords:
Exerciseaddictionanimal modelsmethamphetamineneurogenesisneuronal plasticityneurotoxicity syndromesrelapsereward

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Area of Science:

  • Neuroscience
  • Addiction Research
  • Pharmacology

Background:

  • Methamphetamine addiction presents a growing public health challenge with limited FDA-approved treatments.
  • The complex neurobiology of addiction, especially relapse, hinders effective therapeutic development.
  • Preclinical evidence suggests voluntary exercise may be a viable intervention for methamphetamine dependence.

Purpose of the Study:

  • To review animal models examining the interaction between exercise and methamphetamine addiction.
  • To highlight the effects of methamphetamine and exercise on neuronal plasticity and neurotoxicity.
  • To present mechanisms by which exercise may attenuate methamphetamine intake and prevent relapse.

Main Methods:

  • Review of preclinical studies utilizing animal models of methamphetamine addiction.
  • Analysis of research investigating voluntary exercise as an intervention.
  • Examination of studies focusing on neurobiological changes in key brain regions (striatum, hippocampus, prefrontal cortex).

Main Results:

  • Methamphetamine disrupts normal brain function, impacting neuronal plasticity and causing neurotoxicity.
  • Voluntary exercise appears to prevent or reduce these disruptions.
  • Exercise demonstrates potential in attenuating methamphetamine intake and preventing relapse-seeking behaviors in animal models.

Conclusions:

  • Exercise may serve as a crucial intervention to combat methamphetamine addiction.
  • Understanding exercise-mediated neurobiological changes is key to developing novel therapeutic strategies.
  • Further research into exercise as an addiction treatment is warranted.