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Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study

Daniel Baier1, Andrej Teren2,3, Kerstin Wirkner2

  • 1Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
|May 17, 2018
PubMed

Insights

Arterial stiffness, measured by pulse wave velocity (PWV), is significantly influenced by age and blood pressure. This large study provides age-dependent reference values for PWV, aiding clinical practice.

Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Public Health

Background:

  • Arterial stiffness parameters, like pulse wave velocity (PWV), are emerging as independent cardiovascular risk factors.
  • Large-scale population studies are needed to establish normal and reference values for these parameters.

Purpose of the Study:

  • To analyze three PWV parameters (brachial-ankle, brachial-femoral, carotid-femoral) in the LIFE-Adult study.
  • To identify risk factors, normal, and reference values for these PWV parameters.
  • To assess the clinical utility of different PWV measurements.

Main Methods:

  • Pulse wave velocity (PWV) was measured using the Vicorder device in 8509 participants aged 19-80.
  • Statistical analysis was performed to determine correlations between PWV parameters and various factors.
  • Age-dependent percentiles were calculated for the general population and a normotonic subgroup.

Main Results:

  • Age and blood pressure were the primary determinants of all analyzed PWV parameters, explaining over 18% of variability.
  • Sex influenced brachial-femoral (bfPWV) and carotid-femoral (cfPWV) but not brachial-ankle (baPWV).
  • Age-dependent reference values showed a strong increase with age, with greater differences between normotonic and general populations in older individuals.

Conclusions:

  • Age and blood pressure significantly impact arterial stiffness, supporting its role in cardiovascular disease.
  • The study provides the largest dataset for age-dependent PWV reference values, facilitating clinical implementation.
  • Brachial-ankle PWV (baPWV) may serve as a practical alternative to carotid-femoral PWV (cfPWV) due to its strong associations and ease of use.
Abstract

Keywords:
Arterial stiffnessBlood pressureBrachial to ankleBrachial to femoralCardiovascular risk stratificationCarotid to femoral

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