2-Methacryloyloxyethyl phosphorylcholine (MPC)-polymer suppresses an increase of oral bacteria: a single-blind,

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2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
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2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

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Natsumi Fujiwara1,2, Hiromichi Yumoto3, Koji Miyamoto4

  • 1Department of Oral Microbiology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8504, Japan. nfujiwara@tokushima-u.ac.jp.

Clinical Oral Investigations
|May 17, 2018
PubMed
Abstract

Insights

2-methacryloyloxyethyl phosphorylcholine (MPC)-polymer mouthwash significantly reduced oral bacteria, including Fusobacterium nucleatum, in a clinical trial. This biomimetic polymer shows potential for controlling oral microflora and preventing infections.

Area of Science:

  • Biomaterials Science
  • Oral Microbiology
  • Polymer Chemistry

Background:

  • Biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymers mimic biomembranes.
  • MPC-polymers are known to reduce protein adsorption and bacterial adhesion.
  • Their efficacy in suppressing oral bacterial adherence requires further investigation.

Purpose of the Study:

  • To evaluate the effectiveness of a 5% MPC-polymer mouthwash in suppressing bacterial adherence in the oral cavity.
  • To investigate the impact of MPC-polymer on the number of Fusobacterium nucleatum, a key dental plaque bacterium.

Main Methods:

  • A randomized, placebo-controlled, single-blind, crossover study with 20 healthy subjects.
  • Evaluation of a 5% MPC-polymer mouthwash versus a phosphate-buffered saline (PBS) control.
  • Bacterial counts determined by electronic counter, culture methods, and quantitative PCR (q-PCR) for total bacteria and F. nucleatum.

Main Results:

  • A significant decrease in total bacteria and oral streptococci counts was observed 5 hours post-treatment with MPC-polymer mouthwash compared to the control.
  • Quantitative PCR analysis revealed a significant reduction in the DNA amounts of total bacteria and F. nucleatum.

Conclusions:

  • MPC-polymer coating in the oral cavity demonstrates potential for suppressing oral bacterial adherence.
  • MPC-polymer is a promising compound for managing oral microflora and preventing oral infections.
Keywords:
2-Methacryloyloxyethyl phosphorylcholineClinical studyFusobacterium nucleatumOral bacteriaOral infection

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