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Oxidation resistance 1 is a novel senolytic target

Xin Zhang1, Suping Zhang1,2, Xingui Liu1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Aging Cell
|May 17, 2018
PubMed
Summary

Piperlongumine (PL) is a senolytic agent that targets oxidation resistance 1 (OXR1). Degrading OXR1 selectively kills senescent cells, offering a new therapeutic strategy for age-related diseases.

Keywords:
OXR1cellular senescencepiperlonguminereactive oxygen species

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