Related Experiment Video

Updated: Feb 10, 2026

Targeted Expression of GFP in the Hair Follicle Using Ex Vivo Viral Transduction
05:28

Targeted Expression of GFP in the Hair Follicle Using Ex Vivo Viral Transduction

Published on: March 17, 2008

11.3K

New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies

Barbara Marzani1, Daniela Pinto1, Elisabetta Sorbellini2

  • 1Giuliani S.p.A., Milan, Italy.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|May 17, 2018
PubMed
Abstract

Insights

N1-methylspermidine enhances autophagy, reducing hair loss and stimulating growth. A topical lotion containing N1-methylspermidine and Sandalore® proved safe and effective in clinical trials for hair regrowth.

Area of Science:

  • Dermatology and Hair Biology
  • Cellular Biology and Molecular Mechanisms
  • Pharmacology and Cosmetology

Background:

  • Hair loss is a significant concern, prompting research into hair cycle regulation and dysregulation.
  • Novel therapeutic targets, including olfactory receptors and autophagy, are emerging for hair growth control.
  • N1-methylspermidine, a spermidine analogue, is investigated for its potential pro-autophagic effects.

Purpose of the Study:

  • To evaluate the in vitro pro-autophagic effect of N1-methylspermidine.
  • To assess the safety and efficacy of a topical lotion containing N1-methylspermidine and Sandalore® in a clinical trial.
  • To investigate the impact on hair loss and hair growth in subjects with chronic telogen effluvium.

Main Methods:

  • In vitro monitoring of autophagic modulation using LC3 and p62 fluorescent signals.
  • Double-blind, placebo-controlled clinical trial involving 60 male and female subjects.
  • Non-invasive objective evaluations of hair loss reduction and hair growth stimulation.

Main Results:

  • N1-methylspermidine demonstrated an increased autophagic process in vitro.
  • The lotion significantly reduced hair loss and stimulated hair growth (density, diameter, anagen hair %, Hair Mass Index) after 3 months.
  • Efficacy persisted 3 months post-treatment, except for hair lost during washing.

Conclusions:

  • Daily application of the N1-methylspermidine and Sandalore® lotion is effective for counteracting hair loss.
  • The lotion promotes hair growth through a multifunctional targeting approach.
  • The study confirms the safety and anti-hair loss efficacy of the investigated topical treatment.

More Related Videos

CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy08:22

CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy

Published on: March 12, 2018

15.6K
Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations14:33

Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations

Published on: October 1, 2013

14.9K

Related Concept Videos

Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
2.5K
Hair Cells01:22

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
45.1K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.9K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

4.0K
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
4.5K
Equivalence: In Vitro and In Vivo Bioequivalence01:17

Equivalence: In Vitro and In Vivo Bioequivalence

Body:Bioequivalence studies are crucial in evaluating whether new drugs can match an approved one regarding pharmacological effects and clinical performance. These studies test if drugs, despite different dosage forms, share identical plasma concentration-time profiles. Three types of equivalence are central to these studies: chemical, pharmaceutical, and therapeutic. Chemical equivalence indicates that two or more drug products contain identical active ingredients in equal amounts.
241