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Updated: Feb 10, 2026

Orthotopic Liver Transplantation in Rats
Published on: July 1, 2012
Administering RiaSTAP for Congenital Afibrinogenemia During Liver Transplant
Chris Giordano1, Chris Johnson, Janice Lawson
1From the Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Abstract:
Liver transplant has occasionally been performed in the presence of congenital afibrinogenemia and has been rarely used to treat it. Historically, to safely manage coagulopathy during transplant, these patients have been administered a combination of fresh frozen plasma and cryoprecipitate. In this case report, we discuss the first reported use of recombinant fibrinogen to treat such a patient and the decision-making process considered to balance the thrombotic and hemorrhagic risks.
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