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Published on: July 14, 2023
Avoidable drug-gene conflicts and polypharmacy interactions in patients participating in a personalized medicine
Kristen K Reynolds1,2, Deanne L Pierce, Frederick Weitendorf1,3
1PGXL Laboratories, Louisville, KY 40202, USA.
Aim:
Determine the ability of a pharmacogenetic service, PRIMER, to identify drug-gene (DGI) and drug-drug interactions (DDI) in patients across multiple conditions. PRIMER consists of patient selection criteria, a gene panel and actionable guidance for DGIs and DDIs.
Results:
The average patient was prescribed 12 medications. PRIMER identified significant DGIs in 73% of patients tested, with 43% having more than one DGI. DDIs were found in 87% of patients. The most common actionable DGIs were for opioid, psychotropic and cardiovascular medications.
Conclusion:
The pairing of patient selection criteria, a multigene panel with evidence-based interpretation and review of DDIs maximizes the patients tested who have actionable benefit and alerts physicians to potentially critical adjustments needed for the patient's medication regimen.
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