Related Experiment Video
Updated: Feb 10, 2026

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
Published on: November 28, 2016
Detecting novel genes for low-density lipoprotein cholesterol in European population using bioinformatics analysis
Huan Zhang1,2, Xing-Bo Mo1,2,3, Tan Xu1,2
1Jiangsu Key Laboratory of Preventive & Translational Medicine for Geriatric Diseases, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, PR China.
Aim:
The aim of this study was to identify related genes for low-density lipoprotein cholesterol and evaluate the functional relevance to provide evidences for prioritizing these genes.
Materials & Methods:
We performed a gene-based association study in about 188,578 individuals. Furthermore, we performed bioinformatics analyses to support the identified genes.
Results:
A total of 292 genes were found to be significant after Bonferroni correction (p < 2.3 × 10-6). Among these genes, 59 seemed to be associated with coronary artery disease (CAD).
Conclusion:
The evidence obtained from the analyses of this study signified the importance of many genes, for example, LDLR, ABCG5, ABCG8, APOB, HNF1A, PTPN11, APOA5 and MCM6, which were also associated with CAD. The findings might provide more insights into the genetic basis of lipid metabolism and CAD.
Related Concept Videos
What is Population Genetics?
Analysis of Population Pharmacokinetic Data
Cholesterol: Significance and Regulation
Considering cholesterol and...
Conservation of Small Populations
Population Growth
What are Populations and Communities?

