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Characterization of cardiorespiratory phase synchronization and directionality in late premature and full term

Maristella Lucchini1,2, Nicolò Pini1,2, William P Fifer1

  • 1Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York, NY, United States of America.

Physiological Measurement
|May 17, 2018
PubMed

Insights

Cardiovascular and respiratory rhythms in newborns show directionality influenced by gestational age and sleep state. This research aids in understanding risks for late preterm infants and developing early markers for cardiorespiratory dysregulation.

Area of Science:

  • Physiology
  • Neonatal Medicine
  • Systems Biology

Background:

  • Physiological subsystems exhibit rhythmic activity with early developmental interdependencies.
  • Traditional analysis quantifies interaction strength but lacks directional insights.
  • Cardiorespiratory coupling irregularities are linked to infant pathologies.

Purpose of the Study:

  • To quantify phase coupling and its directionality between cardiovascular and respiratory systems in newborns.
  • To investigate the influence of gestational age (GA) on cardiorespiratory phase synchronization and coupling directionality.
  • To assess the impact of sleep state on these cardiorespiratory interactions.

Main Methods:

  • Developed a methodological application to quantify phase coupling and directionality.
  • Analyzed data from newborn infants between 35 and 40 weeks of gestational age.
  • Examined the relationship between gestational age, sleep state, and cardiorespiratory coupling dynamics.

Main Results:

  • Cardiorespiratory coupling directionality varied significantly with gestational age.
  • Sleep state also demonstrated a notable influence on the directionality profile.
  • Identified distinct patterns of interaction based on GA and sleep condition.

Conclusions:

  • Findings contribute to understanding risks associated with late preterm birth.
  • Directionality of cardiorespiratory coupling is modulated by GA and sleep.
  • Developed parameters may serve as early diagnostic markers for infant cardiorespiratory dysregulation.
Abstract

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