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[Issues of antithrombotic therapy in ACS patients with atrial fibrillation]

N A Kaydalova1, L Y Koroleva1, G V Kovaleva2

  • 1Federal State Budgetary Educational Institution of Higher Education, "Nizhny Novgorod State Medical Academy" of the Ministry of Health of the Russian Federation.

Kardiologiia
|May 17, 2018
PubMed

Insights

This review covers atrial fibrillation (AF) after acute coronary syndrome (ACS). It examines antithrombotic therapies, including warfarin and novel oral anticoagulants, for patients with both conditions.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Pharmacology

Background:

  • Atrial fibrillation (AF) is a common complication following acute coronary syndrome (ACS).
  • The clinical significance of AF in the context of ACS requires careful management.
  • Antithrombotic therapy is crucial for managing patients with both AF and ACS.

Purpose of the Study:

  • To review current understanding of AF prevalence and clinical significance post-ACS.
  • To describe contemporary strategies for antithrombotic therapy administration.
  • To evaluate clinical studies on warfarin and new oral anticoagulants (NOACs) in combination therapy for AF and ACS patients.

Main Methods:

  • Literature review of existing studies and guidelines.
  • Analysis of antithrombotic treatment approaches.
  • Synthesis of data on warfarin and NOACs in combination therapy.

Main Results:

  • Prevalence and impact of AF following ACS discussed.
  • Modern antithrombotic therapy administration strategies outlined.
  • Evidence from clinical studies on combined warfarin and NOACs presented.

Conclusions:

  • Effective antithrombotic strategies are vital for patients with AF and ACS.
  • Warfarin and NOACs play key roles in combination therapy.
  • Further research may refine optimal treatment protocols.

Keywords:
atrial fibrillation, acute coronary syndrome, antithrombotic therapy, triple antithrombotic therapy, new oral anticoagulants, warfarin, dabigatran, rivaroxaban, apixaban

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