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Trained Microglia Trigger Memory Loss

Iva Lelios1, Melanie Greter1

  • 1Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

Immunity
|May 17, 2018
PubMed

Insights

Innate immune training allows immune cells to remember inflammation. Peripheral inflammation can persistently alter microglia function, impacting later-life neuropathology.

Area of Science:

  • Neuroimmunology
  • Cellular immunology
  • Inflammation research

Background:

  • Innate immune training is a newly identified mechanism.
  • Innate cells can retain memory of prior inflammatory events.

Purpose of the Study:

  • To investigate the long-term effects of peripheral inflammation on microglia.
  • To understand how inflammation influences neuropathology.

Main Methods:

  • Utilized mouse models to study microglia function.
  • Induced peripheral inflammation and assessed long-term cellular changes.

Main Results:

  • Peripheral inflammation can lead to lasting alterations in microglia function.
  • These microglia changes are linked to neuropathology development later in life.

Conclusions:

  • Peripheral inflammation has enduring consequences on innate immune cells, specifically microglia.
  • This highlights a potential mechanism linking early-life inflammation to later neurological disorders.

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