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Updated: Feb 10, 2026

Orthotopic Hind-Limb Transplantation in Rats
Published on: July 12, 2010
Effect of cilostazol in experimental model of degloving injuries in rat limbs
André Pazio1, Vital Burko Santos2, Guataçara Schenfelder Salles Junior3
1MD, Resident, Division of Plastic Surgery, Department of Surgery, Clinics Hospital, Universidade Ferederal do Paraná (UFPR), Curitiba-PR, Brazil. Scientific and intellectual content of the study, analysis and interpretation of data, technical procedures, statistical analysis, manuscript preparation and writing.
Purpose:
To evaluate the effect of the cilostazol on the evolution of partially avulsed flaps, using experimental model of cutaneous degloving in rat limbs.
Methods:
A controlled and randomized experimental study was carried out in which the blood flow and the percentage of flap necrosis were evaluated. We compared the study group, which received cilostazol, and the control group, which received enteral saline solution in the postoperative period. The blood flow in the flap was evaluated through Laser Doppler flowmetry, and a planimetry using the IMAGE J® software was employed for the calculation of the area of necrosis.
Results:
Enteral administration of cilostazol was associated with a higher mean blood flow in all regions of the flap, with a statistically significant difference in the proximal and middle regions (p<0.001) and a lower percentage of necrotic area in the flap (p<0.001).
Conclusion:
Postoperative enteral administration of cilostazol increased blood flow and decreased the total area of necrosis of avulsed cutaneous flaps of rat limbs.
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