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Updated: Feb 10, 2026

Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
Published on: April 15, 2021
Impact of dexmedetomidine on hemodynamics in rabbits
Jianjun Ren1, Changfa Li2, Shuxian Ma3
1Professor, Department of Anesthesiology, the Second Hospital of Hebei Medical University, Shijiazhuang, China. Conception, design, intellectual and scientific content of the study; manuscript writing; critical revision; final approval the manuscript.
Purpose:
To evaluate the effects of single intravenous administration of Dexmedetomidine (DEX) on hemodynamics in rabbits.
Methods:
A total of 32 New Zealand white rabbits were randomly divided into the control group (Group C), Group D1 (2.75 μg/kg), Group D2 (5.5 μg/kg), and Group D3 (8.25 μg/kg) to compare systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), central venous pressure (CVP), left ventricular systolic pressure (LVSP), left ventricular end-stage diastolic pressure (LVEDP), left ventricular developmental pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax at different time points.
Results:
The levels of SBP, DBP, HR, LVSP, and LVEDP in Group D1, D2, and D3 were lower than that of Group C from T1 to T5 (P<0.05), but there was no significant difference at T6 and T7 (P>0.05). Compared with T0, the levels of SBP, DBP, HR, LVSP, LVEDP, and left arterial pressure (LAP) from T1 to T7 were decreased (P<0.05), but there was no significant difference in the other indexes (P>0.05).
Conclusion:
Dexmedetomidine can decrease blood pressure and heart rate in rabbits in a dose-dependent manner, but there is no effect on the myocardial systolic and diastolic function.
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