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[Rhinocerebral Mucormycosis].

Anke Mertens1, Doreen Barche1, Laszlo Scheinpflug1

  • 1Universitätsklinikum Magdeburg HNO.

Laryngo- Rhino- Otologie
|May 17, 2018
PubMed
Summary

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This case study details a severe Mucormycosis infection in a diabetic patient, highlighting rapid progression and complex management. Despite aggressive treatment, the patient experienced significant complications but eventually recovered.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Radiology

Background:

  • Mucormycosis is a rare, aggressive fungal infection, particularly dangerous in immunocompromised individuals.
  • Uncontrolled diabetes mellitus is a significant risk factor for invasive fungal infections.

Observation:

  • A 47-year-old female presented with ptosis and high blood sugar.
  • Imaging revealed ethmoid sinus involvement, orbital fat increase, and ocular muscle extension.
  • The patient experienced vision loss and required extensive surgical intervention.

Findings:

  • Microbial analysis confirmed Mucormycosis (Lichtheimia) infection.
  • Despite high-dose antifungal therapy (Liposomal Amphotericin B, Posaconazole) and strict glycemic control, the infection progressed.

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  • Complications included recurrent sepsis, renal insufficiency, epidural hematoma, and cerebral microinfarcts.

    • Implications:

    • This case underscores the critical need for early diagnosis and aggressive management of Mucormycosis, especially in diabetic patients.
    • Multidisciplinary care involving ophthalmology, infectious diseases, and neurosurgery is crucial for managing such complex cases.
    • Despite severe complications, successful long-term recovery is possible with persistent and comprehensive treatment strategies.