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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Related Experiment Video

Updated: Feb 10, 2026

Methylated DNA Immunoprecipitation
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DNA methylation in personalized medicine.

Muhammad A Budiman1, Steven W Smith2, Jared M Ordway3

  • 1Orion Genomics, LLC, 4041 Forest Park Ave., St Louis, MO 63108, USA.

Personalized Medicine
|May 18, 2018
PubMed
Summary

DNA methylation, a key epigenetic factor, shows promise as biomarkers for personalized medicine. Advanced technologies enable genome-wide profiling to understand epigenetics in health and disease.

Keywords:
companion diagnosticsepigeneticsloss of imprintingnext-generation sequencingtechnology

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Area of Science:

  • Epigenetics
  • Genomics
  • Biomarker Discovery

Background:

  • Epigenetics plays a crucial role in development and gene expression.
  • DNA methylation is a fundamental epigenetic modification directly associated with the genome.
  • Epigenetic alterations are implicated in various diseases, including cancer.

Purpose of the Study:

  • To review the potential of DNA methylation biomarkers in personalized medicine.
  • To discuss current and novel technologies for genome-wide DNA methylation profiling.
  • To forecast the application of these technologies in advancing personalized medicine.

Main Methods:

  • Review of existing literature on DNA methylation biomarkers.
  • Discussion of standard and emerging genome-wide DNA methylation profiling technologies.
  • Analysis of future applications in personalized medicine.

Main Results:

  • Evidence supports DNA methylation biomarkers for personalized medicine.
  • A range of technologies exist for genome-wide DNA methylation analysis.
  • These approaches can enhance understanding of epigenetics in health and disease.

Conclusions:

  • DNA methylation biomarkers hold significant promise for personalized medicine.
  • Technological advancements facilitate comprehensive epigenomic profiling.
  • Integrating epigenomic insights will drive progress in personalized medicine and disease management.