DNA methylation in personalized medicine
Related Experiment Video
Updated: Feb 10, 2026

Methylated DNA Immunoprecipitation
Published on: January 2, 2009
Muhammad A Budiman1, Steven W Smith2, Jared M Ordway3
1Orion Genomics, LLC, 4041 Forest Park Ave., St Louis, MO 63108, USA.
Abstract:
The importance of epigenetics in normal development and tissue-specific gene expression, as well as in diseases such as cancer, is well established. DNA methylation is a primary epigenetic modification that is directly linked to the genome itself. Here, we review evidence supporting the promise of DNA methylation-based biomarkers in personalized medicine, discuss standard and emerging technologies for profiling DNA methylation on a genome-wide scale, and forecast how these approaches will be used in parallel to better understand the epigenetics of health and disease and apply that knowledge to advance the field of personalized medicine.
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