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Updated: Feb 10, 2026

The Use of Chemostats in Microbial Systems Biology
Published on: October 14, 2013
Surgical systems biology and personalized longitudinal phenotyping in critical care
Laura J Muirhead1, James Kinross1, Thomas S FitzMaurice1
1Section of Biosurgery & Surgical Technology, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, 10th Floor, Queen Elizabeth the Queen Mother Building, St Mary's Hospital, London, W2 1NY, UK.
Abstract:
Systems-wide molecular analysis of the metabolic, inflammatory and immune response to surgical trauma has yet to be translated into the operating room. Surgical patients are exposed to a large number of heterogeneous environmental insults that cannot only be quantified by genome-orientated 'omics platforms. Furthermore, surgery demands rapid or near real-time analysis. Systems-level metabolic phenotyping provides a novel 'global' perspective of an organism's metabolic response to surgical injury and, therefore, serves as an ideal platform for the development of personalized therapies in surgery. This article reviews current personalized approaches to healthcare in surgery and explores future directions for personalized surgical biomarker discovery and therapeutics. In particular, this article discusses our vision of 'personalized metabolic phenotyping' in surgery, and outlines next-generation technologies that will make this approach a reality.
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