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Related Concept Videos

Pancreas01:19

Pancreas

2.5K
The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
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Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

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The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
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Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.4K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Updated: Feb 10, 2026

Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation
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Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation

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Pancreas regeneration.

Qiao Zhou1,2, Douglas A Melton3,4,5

  • 1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. qiao_zhou@harvard.edu.

Nature
|May 18, 2018
PubMed
Summary
This summary is machine-generated.

Restoring pancreatic beta-cell mass is crucial for treating type 1 diabetes. Researchers are exploring stem cell therapies and other innovative strategies for pancreatic regeneration.

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Collection Protocol for Human Pancreas
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Collection Protocol for Human Pancreas

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Last Updated: Feb 10, 2026

Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation
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Isolation and Decellularization of a Whole Porcine Pancreas
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Area of Science:

  • Endocrinology
  • Regenerative Medicine
  • Cell Biology

Background:

  • The pancreas has exocrine and endocrine functions, producing digestive enzymes and insulin, respectively.
  • Loss of insulin-producing beta-cells in type 1 diabetes necessitates therapeutic strategies.
  • Human islets have limited capacity for regeneration.

Purpose of the Study:

  • To review current therapeutic approaches for restoring beta-cell mass.
  • To highlight the potential of various strategies in pancreatic regeneration.

Main Methods:

  • Review of current research in beta-cell regeneration.
  • Analysis of stem cell-derived beta-cell generation and transplantation.
  • Evaluation of alternative approaches like endogenous cell proliferation and cell reprogramming.

Main Results:

  • Human pluripotent stem cells offer a promising source for generating new beta-cells.
  • Stimulating endogenous beta-cell proliferation and reprogramming non-beta-cells are viable alternative strategies.
  • Xenotransplantation of islets from genetically engineered animals is also under investigation.

Conclusions:

  • A diverse range of therapeutic strategies are being developed for pancreatic regeneration.
  • These approaches aim to restore beta-cell mass and function for diabetes treatment.