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Esophageal Perforation-I: Introduction01:22

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Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
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Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging MRI
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Nilotinib-induced Perforating Folliculitis: Two Cases.

Neerja Saraswat1, Ajay Chopra1, Debdeep Mitra1

  • 1Department of Dermatology, Base Hospital Delhi Cantt, New Delhi, India.

International Journal of Trichology
|May 18, 2018
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Summary

Cutaneous adverse effects from chemotherapy are common but often missed. This study highlights two cases of perforating folliculitis caused by nilotinib, a tyrosine-kinase inhibitor for chronic myeloid leukemia.

Keywords:
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Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Chemotherapy agents, including newer tyrosine-kinase inhibitors, can cause various cutaneous adverse effects.
  • These side effects are often underreported and may be overlooked by patients and physicians.
  • Nilotinib, a second-generation tyrosine-kinase inhibitor, is increasingly used for chronic myeloid leukemia.

Observation:

  • Two cases of perforating folliculitis were observed.
  • These cases were specifically induced by nilotinib treatment.
  • Perforating folliculitis is a notable, though sometimes overlooked, dermatologic manifestation.

Findings:

  • Nilotinib can induce perforating folliculitis as a cutaneous adverse effect.
  • The occurrence of this specific side effect highlights the need for vigilance in monitoring patients on nilotinib.
  • Early recognition and management of such effects are crucial for patient care.

Implications:

  • Increased awareness of nilotinib-induced perforating folliculitis is necessary for oncologists and dermatologists.
  • Prompt identification and management can prevent complications and improve patient adherence to therapy.
  • Further research into the mechanisms and incidence of nilotinib-related dermatologic toxicities is warranted.