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Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
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Developing a cells, tissue and organ surveillance system.

Z Hong1, P Kenny1, C Hyson1

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Area of Science:

  • Transplantation Science
  • Public Health Surveillance
  • Patient Safety

Background:

  • Increasing volume of cell, tissue, and organ transplants in Canada.
  • Public Health Agency of Canada is developing a Cell, Tissue and Organ Surveillance System (CTOSS).

Purpose of the Study:

  • To generate timely, relevant national data on transplantation adverse events.
  • Enhance provincial and territorial data collection systems for transplantation surveillance.

Main Methods:

  • Established minimum data elements and definitions for tissue transplants, referencing EU and US standards.
  • Initiated data collection on adverse events for human allograft tissue transplants in April 2011 at pilot sites across Canada.

Main Results:

  • By December 2013, eight adverse events related to tissue transplantation were reported.
  • The reported events included seven cases involving corneal tissue and one involving cardiovascular tissue.

Conclusions:

  • A comprehensive Cell, Tissue and Organ Surveillance System (CTOSS) can enhance patient safety in Canada.
  • Improved data collection and analysis will deepen understanding of transplantation adverse events, informing prevention strategies and reducing event severity.
  • Future development includes defining data elements for cell and organ transplants and expanding pilot site participation.