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The production of tumor necrosis factor-alpha by rat basophilic leukemia cells with triggering IgE receptor
1The First Department of Internal Meicine, Tohoku University School of Medicine, Sendai.
The Tohoku Journal of Experimental Medicine
|October 1, 1988
Abstract:
We evaluated cytotoxic factor released from rat basophilic leukemia cells (RBL) sensitized with anti-ovalbumin (OVA) mouse serum after incubation with OVA. The cytotoxic activity of this factor was completely blocked by anti-mouse tumor necrosis factor-alpha (mTNF-alpha) specific antibody. Therefore, we concluded that by triggering the IgE receptor, RBL could produce and release TNF-alpha.