Related Experiment Video

Updated: Feb 10, 2026

Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
08:08

Cardiopulmonary Bypass in a Mouse Model: A Novel Approach

Published on: September 22, 2017

11.6K

Recent innovations in perfusion and cardiopulmonary bypass for neonatal and infant cardiac surgery

David Sturmer1, Claude Beaty2, Sean Clingan3

  • 1Department of Perfusion, University of Michigan C.S. Mott Children's Hospital, Ann Arbor, MI, USA.

Translational Pediatrics
|May 18, 2018
PubMed

Insights

Cardiopulmonary bypass (CPB) innovations reduce complications in infant heart surgery. This review details advancements in blood transfusions, circuit design, and monitoring to improve patient outcomes and minimize morbidity.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Surgery
  • Biomedical Engineering

Background:

  • Cardiopulmonary bypass (CPB) enables complex congenital heart defect repairs in neonates and infants.
  • Historically, survival was the primary goal; now, reducing morbidity is paramount.
  • CPB, while essential, can cause significant perioperative complications.

Purpose of the Study:

  • To review recent innovations aimed at mitigating CPB-related risks in pediatric cardiac surgery.
  • To highlight advancements in minimizing morbidity associated with CPB.

Main Methods:

  • Review of recent innovations in CPB.
  • Discussion of improvements in specific areas: blood transfusions, circuit design, monitoring, perfusion techniques, temperature management, and myocardial protection.

Main Results:

  • Significant advancements have been made in reducing blood transfusions during CPB.
  • Innovations in CPB circuit design and monitoring enhance patient safety.
  • Improved perfusion techniques, temperature management, and myocardial protection strategies minimize complications.

Conclusions:

  • Recent innovations have substantially improved the safety and reduced the morbidity of CPB in infant cardiac surgery.
  • Continued systematic improvements in CPB are crucial for further enhancing patient outcomes.

Keywords:
Neonatal cardiac surgerybiomarkercardioplegiacardiopulmonary bypass (CPB)hypothermiamonitoringperfusiontransfusion

More Related Videos

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children07:27

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

12.6K
A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats09:54

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Published on: March 23, 2018

8.4K

Related Concept Videos

Cardiopulmonary Resuscitation I: Adult01:21

Cardiopulmonary Resuscitation I: Adult

Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
765
Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
749
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
324
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
865
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
694
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
595