Related Experiment Video

Updated: Feb 10, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Direct-acting antiviral agents in patients with hepatitis C genotype 1-4 infections in a tertiary hospital

J C Del Rio-Valencia1, R Asensi-Diez, L Villalobos-Torres

  • 1Juan Carlos del Rio-Valencia, Hospital Regional Universitario de Málaga. Avenida de Carlos Haya s/n. CP.29010. Málaga. Spain. juancardelrio@telefonica.net.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|May 18, 2018
PubMed

Insights

Direct antiviral agents (DAAs) demonstrate high sustained virologic response rates (SVR12) in real-world Hepatitis C virus (HCV) patients across genotypes 1-4. Treatment regimens showed significant efficacy, confirming clinical trial data.

Area of Science:

  • Hepatology
  • Virology
  • Clinical Medicine

Background:

  • Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease.
  • Six HCV genotypes (GT 1-6) exist, with genotype influencing treatment efficacy of direct antiviral agents (DAAs).

Purpose of the Study:

  • To describe clinical characteristics of real-world HCV patients.
  • To evaluate the effectiveness of various DAA-based treatment regimens.

Main Methods:

  • Retrospective, observational study of 515 HCV patients (January 2015-January 2016).
  • Patients received 12-week DAA regimens, with or without ribavirin (RBV) or pegylated interferon (Peg-IFN).
  • Primary endpoint: sustained virologic response 12 weeks post-treatment (SVR12).

Main Results:

  • High SVR12 rates observed across genotypes 1-4 with different DAA combinations.
  • Genotype 1: SVR12 rates ranged from 87.5% to 98.82%.
  • Genotype 3: SVR12 rates varied from 43.75% to 95% depending on the regimen.

Conclusions:

  • Real-world DAA treatment confirms efficacy reported in clinical trials for HCV genotypes 1-4.
  • Diverse patient characteristics were managed effectively by the evaluated treatment regimens.
Abstract

More Related Videos

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V311:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

12.8K
Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

18.9K

Related Concept Videos

Adrenergic Agonists: Direct-Acting Agents01:30

Adrenergic Agonists: Direct-Acting Agents

Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
These agents can be classified...
2.9K
Direct-Acting Cholinergic Agonists: Pharmacokinetics01:31

Direct-Acting Cholinergic Agonists: Pharmacokinetics

Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
1.9K
Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
1.2K
Adrenergic Agonists: Indirect-Acting Agents01:25

Adrenergic Agonists: Indirect-Acting Agents

Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
2.8K
Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
1.8K
Hospitals-I01:28

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.7K