Related Experiment Video

Updated: Feb 10, 2026

Qualitative and Quantitative Assays for Detection and Characterization of Protein Antimicrobials
10:50

Qualitative and Quantitative Assays for Detection and Characterization of Protein Antimicrobials

Published on: April 10, 2016

19.1K

Return of the tetracyclines: omadacycline, a novel aminomethylcycline antimicrobial

J C Cho1, L M Childs-Kean2, M T Zmarlicka3

  • 1College of Pharmacy, The University of Texas at Tyler, Tyler, Texas, USA. jcho@uttyler.edu.

Drugs of Today (Barcelona, Spain : 1998)
|May 18, 2018
PubMed

Insights

Omadacycline, a novel aminomethylcycline antibiotic, shows potent activity against resistant bacteria. It is a promising treatment for infections like pneumonia and skin infections, with manageable side effects.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Microbiology

Background:

  • Tetracycline resistance is a growing global health concern.
  • Novel antibiotics are needed to combat resistant bacterial strains.
  • Omadacycline is a new aminomethylcycline with unique structural properties.

Purpose of the Study:

  • To evaluate the antimicrobial activity of omadacycline.
  • To assess the efficacy of omadacycline in treating bacterial infections.
  • To characterize the safety and tolerability profile of omadacycline.

Main Methods:

  • In vitro susceptibility testing against resistant pathogens.
  • Clinical studies for community-acquired bacterial pneumonia and skin infections.
  • Monitoring of adverse events in clinical trials.

Main Results:

  • Omadacycline demonstrated potent activity against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and other resistant bacteria.
  • The drug is effective for community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.
  • Gastrointestinal symptoms were the most common adverse effects, indicating good tolerability.

Conclusions:

  • Omadacycline is a promising novel antibiotic agent.
  • Its unique structure overcomes common tetracycline resistance mechanisms.
  • Further studies are ongoing for other indications like cystitis.
Keywords:
Aminomethylcycline antibioticsAntibacterial drugsBacterial pneumoniaBacterial skin infectionsOmadacyclineTetracyclines

More Related Videos

Expression, Purification, and Antimicrobial Activity of S100A1211:10

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

8.8K
Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry06:02

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry

Published on: August 23, 2022

3.6K

Related Concept Videos

Venous Return01:04

Venous Return

The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
12.5K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.0K
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.5K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
472
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.4K
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
8.8K