Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

From DNA to Protein03:06

From DNA to Protein

22.6K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
22.6K
AC Sources01:20

AC Sources

4.1K
Direct current is a flow of electric charge in only one direction and has a steady state of constant voltage in the circuit. Rectifiers, batteries, commutator-equipped generators, and fuel cells are some examples of devices that generate direct current. Nowadays, most applications use a time-varying voltage source. Alternating current is a flow of electric charge that periodically reverses direction. An alternating current is produced by an alternating emf that is generated in a power plant. If...
4.1K
pH Scale02:41

pH Scale

80.3K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
80.3K
Accelerators01:17

Accelerators

292
Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
292
Resistor in an AC Circuit01:31

Resistor in an AC Circuit

3.2K
An alternating emf or voltage source is needed to supply an alternating current (AC) to a circuit. A coil of wire rotating in a magnetic field at a constant angular speed represents such a source. It also generates a sinusoidal alternating emf and serves as an industrial alternator.
One-way current through the meter is measured using diodes. A diode is a device with better conductivity in one direction compared to the other; in its ideal state, it has zero resistance in one direction and allows...
3.2K
Power in an AC Circuit01:26

Power in an AC Circuit

2.3K
In a DC circuit, the power consumed is simply the product of the DC voltage times the DC current, given in watts. However, the power consumed for AC circuits with reactive components is calculated differently. Since electrical power is the "rate" at which energy is used in a circuit, all electrical and electronic components and devices have a safe operating range for electrical power.
In a DC circuit, there is no sinusoidal waveform associated with the supply; the voltages and currents are...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ClairS: a deep-learning method for long-read tumor-normal pair somatic small variant calling.

Nature methods·2026
Same author

Hierarchically Designed Electrospun Passive Daytime Radiative Cooling Metafabric Enabling Moisture Transport and Fire Safety.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

A complete human pancreatic cancer genome.

bioRxiv : the preprint server for biology·2026
Same author

Accelerated long-read variant calling with Clair3 for whole-genome sequencing.

Bioinformatics (Oxford, England)·2026
Same author

Gungnir codec enabling high error-tolerance and low-redundancy DNA storage through substantial computing power.

Nature communications·2026
Same author

EPInformer: scalable and integrative prediction of gene expression from promoter-enhancer sequences with multimodal epigenomic profiles.

Nature communications·2026

Related Experiment Video

Updated: Feb 10, 2026

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

7.2K

AC-DIAMOND v1: accelerating large-scale DNA-protein alignment.

Huijun Mai1, Yifan Zhang2, Dinghua Li1

  • 1Department of Computer Science, University of Hong Kong, Hong Kong.

Bioinformatics (Oxford, England)
|May 18, 2018
PubMed
Summary
This summary is machine-generated.

AC-DIAMOND is a new DNA-protein alignment tool that is 6-7 times faster than previous methods. It efficiently aligns large datasets to protein databases while maintaining high accuracy.

More Related Videos

AC Electrokinetic Phenomena Generated by Microelectrode Structures
20:38

AC Electrokinetic Phenomena Generated by Microelectrode Structures

Published on: July 28, 2008

11.9K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.6K

Related Experiment Videos

Last Updated: Feb 10, 2026

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

7.2K
AC Electrokinetic Phenomena Generated by Microelectrode Structures
20:38

AC Electrokinetic Phenomena Generated by Microelectrode Structures

Published on: July 28, 2008

11.9K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.6K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Aligning DNA reads and contigs to protein databases is computationally intensive.
  • Existing tools like DIAMOND face efficiency challenges with large datasets.

Purpose of the Study:

  • To develop a faster and efficient DNA-protein alignment tool.
  • To improve the speed of aligning large sequence datasets to protein databases.

Main Methods:

  • Developed AC-DIAMOND (v1), a novel DNA-protein alignment tool.
  • Implemented a compressed index of adaptive-length seeds for faster sequence matching.
  • Utilized a compact dynamic programming approach to leverage SIMD parallelism.

Main Results:

  • AC-DIAMOND achieves a 6- to 7-fold speed-up compared to DIAMOND.
  • Maintained a similar level of sensitivity as existing efficient methods.
  • Demonstrated improved efficiency for aligning large amounts of reads or contigs.

Conclusions:

  • AC-DIAMOND offers a significant advancement in DNA-protein alignment efficiency.
  • The tool effectively addresses the challenge of processing large-scale sequence data.
  • AC-DIAMOND provides a valuable resource for genomic and proteomic analyses.