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Updated: Feb 10, 2026

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
Published on: October 2, 2014
Cognitive safety of intracranial electrodes for epilepsy
Kimford J Meador1, Casey H Halpern2, Bruce P Hermann3
1Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA.
Abstract:
Two recent articles in Epilepsia have raised concerns about adverse cognitive effects associated with intracranial electrode implantation. However, both studies have important limitations, and their results contrast with studies that report no adverse cognitive effects of intracranial electrodes for diagnosis or neurostimulation in epilepsy. Furthermore, no data are provided on the relative safety of depth electrodes implanted along the longitudinal axis of the hippocampus vs other electrode locations or types of electrodes. Instituting changes in the use of depth electrodes based solely on these 2 studies is not clinically indicated. Further research is needed.
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