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A multifaceted approach to RSV vaccination

Jorge C G Blanco1, Marina S Boukhvalova1, Trudy G Morrison2

  • 1a Sigmovir Biosystems Inc. , Rockville , MD.

Human Vaccines & Immunotherapeutics
|May 18, 2018
PubMed

Insights

Respiratory Syncytial Virus (RSV) vaccines are in clinical trials for infants, children, women, and the elderly. This review discusses current RSV vaccine candidates and preclinical studies to improve prediction of clinical outcomes.

Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Respiratory Syncytial Virus (RSV) is a major global cause of infant pneumonia and bronchiolitis.
  • RSV circulates year-round, posing risks to infants, the elderly, and immunocompromised individuals.
  • Currently, no approved vaccines exist to prevent RSV infection or mitigate its symptoms.

Purpose of the Study:

  • To review and discuss RSV vaccine candidates in clinical trials.
  • To describe preclinical studies supporting vaccine advancement.
  • To propose novel preclinical models for predicting clinical vaccine trial success.

Main Methods:

  • Literature review of current RSV vaccine clinical trials.
  • Analysis of preclinical data supporting vaccine candidates.
  • Discussion of existing and potential preclinical models for RSV vaccine evaluation.

Main Results:

  • Multiple RSV vaccine candidates are in clinical development targeting diverse populations including infants, children, women, and adults/elderly.
  • Preclinical studies have been crucial for advancing these vaccine candidates.
  • There is a need for improved preclinical models to better predict clinical efficacy and safety.

Conclusions:

  • RSV vaccine development is progressing across various age groups.
  • Advancement relies on robust preclinical data.
  • Enhanced preclinical models are essential for successful RSV vaccine translation to clinical practice.

Keywords:
Cotton ratRSVmaternal immunizationpregnancy

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